Malaria Research

The staff at Travel Bug Vaccination Clinic participated in this important research project.

3 Day Malarone Acceptability and Tolerability research project (3MAT)

Malaria is one of the most common causes of fever in Australian travellers, with approximately 400 cases reported each year in Australia. Most travellers who develop malaria did not take anti-malarial medications, or did not take the medications properly (e.g. forgot to take tablets). Malaria is a serious illness and can potentially be fatal.

A research project is being conducted with the aim to make it easier and cheaper to take malaria pills and thus reduce the risk of malaria in travellers.

Malarone is a safe and effective anti-malarial medication.  The standard dosage of Malarone for prevention of malaria is one tablet per day, starting 2 days before travelling to a malaria area, daily while in a malaria area, and continuing until 7 days after leaving the malaria area.

Research has shown that when people are given a 3-day course of Malarone for treatment of malaria, they are protected from malaria for at least 4 weeks afterwards.

It is therefore possible to protect travellers for 4 weeks by giving them just a 3-day course of Malarone before they go, and no tablets while they are away or on return. This research will assess the acceptability and compliance of the 3-day schedule of Malarone for malaria prevention.

Participants will be recruited from two specialist travel medicine clinics:

OURS - Travel Bug Vaccination Clinic, 182 Ward St North Adelaide

Dr Deb - The Travel Doctor clinic in Brisbane 

Australians 18 years of age and over, travelling to malaria endemic countries in Asia, the Pacific Islands, or South/Central America for 4 weeks or less are eligible to participate. The study aims to recruit approximately 220 travellers.

On completion of the study, the research team will publish the results in an internationally recognised medical journal so that this important information can be shared with the medical and scientific community to improve the health of travellers. Individuals will not be identified when results are presented or published.

This project does not have any specific funding. It is being conducted by the doctors and nurses at the participating clinics at their own cost, with the aim of improving clinical best practice in travel medicine. Participants pay for their own medication.

To participate in the study, you will be given more information and be requested to attend a pre-travel consultation, take anti-malarial medications, fill in a symptom diary, and complete 3 questionnaires: the day of the visit, the day before departure and one week after return.

Participants will receive detailed information about the trial prior to participation, and can withdraw at any time.


Participant Information Sheet

For further information contact the participating clinics

NP/RN. Lani Ramsey (Adelaide) Email: Phone: (08) 8267 3544

Dr. Deborah Mills (Brisbane) Email: Phone: (07) 3221 9066

This project has ethics approval and is being conducted by the Travel Medicine Alliance in conjunction with the Australian National University in Canberra